A down-and-out band, a girl searching for her father, and Jerry's guitar.

The members of Uncle Joe's Band have spent years playing any venue that will pay for their unintelligible metal band performances while their rock and roll lifestyle has left them with bad livers, multiple divorces, and living in a squalid house in Vallejo, California.

Then one morning everything changes when an assertive twelve-year-old girl named Allison appears on their front porch and announces that she has been sent to stay with her father for the summer.

Meanwhile, years ago, the band's namesake and inspiration, Uncle Joe, takes a long strange trip as a vagabond hippie through the '60s, '70s, and '80s that includes brushes with Ken Kesey's bus, Watergate, the Pet Rock, Iran Contra, and Jerry Garcia.

Inspired by their experience with Allison and their budding paternal instincts, recollections of Uncle Joe, and a well-played Stratocaster with the initials "JG", the members of Uncle Joe's Band begin to play a new tune in a major key.