Trusted anesthesiologist, Dr. Roxanne Roth, is healing from the loss of her fianc by consuming her time with work. It doesn't hurt that her new love interest, Dr. Justin Kirkland, spends almost as much time at the hospital as she does.

Entranced in the throes and complications of new love, Roxanne looks forward to work every day. Her time at the hospital would almost be cathartic if not for Dr. D. K. Webb, a neurosurgeon, who is quickly amassing a pile of complaints - and bodies.

Despite trying to avoid Webb, Roxanne finds herself working alongside the doctor during a routine, low-risk surgery. Fueled by cocaine and ego, Webb intentionally sabotages the case, leading to the patient dying on the operating table.

Roxanne's tenuous grip on recovery is shattered with her patient's death, quickly replaced by anger and a drive for justice. Now Roxanne will do anything to protect her patients from the killer on the other side of the sterile surgical field-before he can silence her as well.