This practical book establishes a solid foundation for understanding the essential principles of how signals interact with transmission lines. These insights are the basis of the best design and best measurement practices for single-ended and differential transmission lines. Readers can confidently use these guidelines to avoid common mistakes. They will learn how to leverage rules of tumb, approximations, 2D filed solvers, and TDR measurements to extract the important figures of merit and obtain an acceptable, verified design, faster. Complex engineering principles are explained in a simplified but practical way.