This Special Issue of Bioengineering explores topics in Pediatric Neuro-Oncology ranging from preclinical modeling to translational research and neurocognitive outcomes. The topics are as below.

1. Radiotherapy advances in pediatric brain tumors;
2. Neurofibromatosis 1 and brain tumors in children;
3. Molecular biology of pediatric gliomas and therapeutic insights;
4. Embryonal tumors of the central nervous system in children-era of targeted therapeutics;
5. Preclinical models in pediatric brain tumors--clinical relevance;
6. Molecular neuroimaging of brain tumors;
7. Palliative care for children with central nervous system malignancies;
8. Neurocognitive and psychosocial outcomes following pediatric brain tumors.