Claire DeWitt, the hard-living and tough-talking private investigator, has always been something of a detective. As a young girl growing up in Brooklyn, Claire and her two best friends, Tracy and Kelly, fell under the spell of the book Detection by legendary French detective Jacques Silette. They solved many cases together, in the process witnessing human behavior at its worst. The three were inseparable--until the day Tracy vanished without a trace. That is still the only case Claire ever failed to solve.

Later, in her twenties, Claire is in Los Angeles trying to get her PI license by taking on a cold case that has stumped the LAPD. She hunts for the real story behind the death of a washed-up painter ten years earlier, whose successful, widely admired artist girlfriend had died a few months before him.

Today, Claire is on her way to Las Vegas when she's almost killed by a homicidal driver. In a haze of drugs and injuries, she struggles off the scene, determined to find her would-be killer's identity but the list of people who would be happy to see her dead is not a short one.

As these three "eccentric, enticingly artful" (Kirkus Reviews, starred review) narratives converge, some mysteries are solved and others continue to haunt. But Claire will continue her search for the answer to the biggest mystery of all: what is the purpose of our lives, and how can anyone survive in a world so clearly designed to break our hearts again and again?