Evil creatures called Nemeses fall from the skies and the only ones who can fight them are Wizards--infected ones who survived a Nemesis's corruption. Seth, one of these survivors, vows not only to fight the Nemeses, but to find their mythical nest, Radiant, and destroy it!

Heading to Bôme in order to retrieve the Nemeses their occasional ally Grimm stole from the Artemis Institute, Seth and his friends are separated while trying to ward off different groups of enemies, including members of a mysterious organization calling themselves the Mesnie. Their one chance of getting out of this mess rests with Doc, their most cowardly and inept companion. (And not at all ashamed of it!) Considering this, do Seth and company have a hope of reaching their destination safely...or at all?