Notes on Nursing: What it is and What it is Not is a book first published by Florence Nightingale in 1859. A 76-page volume with 3 page appendix published by Harrison of Pall Mall, it was intended to give hints on nursing to those entrusted with the health of others. Florence Nightingale stressed that it was not meant to be a comprehensive.

In her introduction to the 1974 edition, Joan Quixley, then head of the Nightingale School of Nursing, wrote that despite the passage of time since Notes on Nursing was published, "the book astonishes one with its relevance to modern attitudes and skills in nursing, whether this be practised at home by the 'ordinary woman', in hospital or in the community. The social, economic and professional differences of the nineteenth and twentieth centuries in no way hinder the young student or pupil from developing, if he or she is motivated to do so, its unchanged fundamentals by way of intelligent thought and practice". "With its mid-nineteenth century background of poverty, neglect, ignorance and prejudice the book was a challenge to contemporary views of nursing, of nurses and of the patient". "The book was the first of its kind ever to be written. It appeared at a time when the simple rules of health were only beginning to be known, when its topics were of vital importance not only for the well-being and recovery of patients, when hospitals were riddled with infection, when nurses were still mainly regarded as ignorant, uneducated persons. The book has, inevitably, its place in the history of nursing, for it was written by the founder of modern nursing"