Lois Pritchard is a GP at the Llangandida Health Centre, as a salaried partner with Drs Robert Smith and Iwan James. She also works two days a week in the local Genitourinary Medicine (GUM) clinic. Currently single, despite the attentions of her many admirers, she is, by her own admission, `not very good with relationships'. Starting guitar lessons on her 40th birthday does not become the release she hopes from life's vicissitudes. When her estranged mother makes a dramatic appearance on the scene, Lois must look to something far more radical to sort out her personal life.

Meanwhile, her patients' stories provide some welcome relief: a man who regrets the Pinocchio face he had tattooed on his genitals; a prescription drug addict who plans to sue his previous doctors for failing to refuse him the drugs he demanded; a health campaigner who vows to starve herself to death if her demands are not met; and a man who resorts to desperate measures after being driven mad by his neighbours' cats.