Jimmy Kudo, the son of a world-renowned mystery writer, is a high school detective who has cracked the most baffling of cases. One day while on a date with his childhood friend Rachel Moore, Jimmy observes a pair of men in black involved in some shady business. The men capture Jimmy and give him a poisonous substance to rub out their witness. But instead of killing him, it turns him into a little kid! Jimmy takes on the pseudonym Conan Edogawa and continues to solve all the difficult cases that come his way. All the while, he's looking for the men in black and the mysterious organization they're with in order to find a cure for his miniature malady.

The death of a private detective puts Conan back on the trail of the mysterious Syndicate. Now he believes he's identified one of the Men in Black--or, rather, a Woman in Black--as American actress Chris Vineyard. But could the elusive mistress of disguise be closer than Conan realizes? When Conan and Harley Hartwell investigate a suicide in the apartment building of daffy English teacher Jodie Santemillion, they discover more than just foul play. Who is Miss Jodie?