In this extraordinary novel, Amitav Ghosh navigates through time and genres to present a unique tale. Beginning at an unspecified time in the future and ranging back to the late nineteenth century, the reader follows the adventures of the enigmatic L. Murugan. An authority on the Nobel Prize-winning scientist Sir Ronald Ross, who solved the malaria puzzle in Calcutta in 1898, Murugan is in search of the elusive 'Calcutta Chromosome'.

With its astonishing range of characters, advanced computer science, religious cults and wonderful portraits of Victorian and contemporary India, The Calcutta Chromosome expands the scope of the novel as we know it, as Amitav Ghosh takes on the avatar of a science thriller writer.