In the small Bosnian town of Visegrad the stone bridge of the novel's title, built in the sixteenth century on the instruction of a grand vezir, bears witness to three centuries of conflict. Visegrad has long been a bone of contention between the Ottoman and Austro-Hungarian Empires, but the bridge survives unscathed until 1914, when the collision of forces in the Balkans triggers the outbreak of World War I.

The bridge spans generations, nationalities and creeds, silent testament to the lives played out on it. Radisav, a workman, tries to hinder its construction and is impaled alive on its highest point; beautiful Fata leaps from its parapet to escape an arranged marriage; Milan, inveterate gamble, risks all in one last game on it. With humour and compassion, Andric chronicles the lives of Catholics, Muslims and Orthodox Christians unable to reconcile their disparate loyalties.