During the fall of 1918, the influenza pandemic crosses the nation and reaches the mining town of Butte, Montana.

Marika Jovich, who wants to go to school to become a physician, works menial tasks for Dr. Fletcher. She feels useless as she tries to save friends and neighbors from the ravages of the flu. In the midst of the pandemic, she watches the town shut down, young and old perish, and her medical dreams all but evaporate.

Kaly Monroe used to be a half-good woman of the night. She left that life to raise her daughter, Annie, and live and work with her long-lost mother, Tara McClane. Kaly waits for her husband, Tommy, to return from the war. Word from the east is that soldiers are dying of influenza and she prays that Tommy is not one of them.

When an out-of-town woman named Amelia suddenly dies in Dr. Fletcher's office, both women try to learn more about the mysterious woman and the circumstances regarding her death. Is she another casualty of the pandemic, or the victim of manmade foul play? Who is this stranger, and is her demise a portent of the fate that awaits the residents of Butte?