Left alone to care for his aging father after his mother dies by suicide and his sister escapes to Yale, Isaac English longs for a life beyond his hometown, a beautiful but economically devastated Pennsylvania steel town. But when he finally sets out to leave for good, accompanied by his temperamental best friend, former high school football star Billy Poe, they are caught up in a terrible act of violence that changes their lives forever.

Evoking John Steinbeck's novels of restless lives during the Great Depression, American Rust takes us into the contemporary American heartland at a moment of profound unrest and uncertainty about the future. It is a dark but lucid vision, a moving novel about the bleak realities that battle our desire for transcendence and the power of love and friendship to redeem us.