In the mid sixteenth century, Henry VIII sits on the throne, and Bianca Goddard tends to the sick and suffering in London's slums, where disease can take a life as quickly as murder...

For years, alchemist Ferris Stannum has devoted himself to developing the Elixir of Life, the reputed serum of immortality. Having tested his remedy successfully on an animal, Stannum intends to send his alchemy journal to a colleague in Cairo for confirmation. But the next day his body is found and the journal is gone.

Bianca, the daughter of an alchemist, is well acquainted with the mystical healing arts. When her husband John falls ill with the sweating sickness, she dares to hope Stannum's journal could contain the secret to his recovery. But first she must solve the alchemist's murder. As she ventures into a world of treachery and deceit, Stannum's death is only the first in a series of murders--and Bianca's quest becomes a matter of life and death, not only for her husband, but for herself...