Dr. Timothy Ryan, head of the military psychiatric unit at Grantham Barracks, is meeting a new patient, a woman known as "Prisoner Alpha." As she is being transferred, they are attacked by assassins, barely escaping with their lives. One shooter vanishes, leaving behind a dead companion unlike anyone Ryan has ever seen.

But even more baffling is the puzzle of Alpha herself. She speaks in a strange tongue, and doodles in bars, dots, and little pictures like nothing Ryan has ever seen. Is she some sort of savant, or the most cunning spy he's ever met?

Meanwhile, in Egypt, archaeologist Reid Farmer uncovers an 18th-Dynasty tomb that shouldn't exist, filled with Mayan epigraphy, mathematics, and materials that didn't exist 3,000 years ago. As a result of this discovery, Reid and forensic anthropologist Kilgore France--along with the sarcophagus they have found--are snatched away to a hidden lab to solve the enigma of a man lost in time.

As dark forces gather, Alpha makes an impossible escape from Grantham. Ryan quickly becomes the prime suspect in her disappearance, but with a team of unique allies, sets out to prove his innocence. Together, they must find Alpha and save Ryan before it is too late.